Since it came onto the market in 1983, glyburide has been one of the most popular sulfonylureas. If the patient does not present obesity, idpp4, isglt2 or gliclazide, sulfonylurea. This was a 74yearold woman with longstanding diabetes on treatment with metformin 850mg12h and lantus insulin 30iu at dinner. Doseresponse relation between sulfonylurea drugs and. Sex and bmi alter the benefits and risks of sulfonylureas and. Cyp2c92 allele increases risk for hypoglycemia in por11 type. Transient electrocardiographic abnormalities during hypoglycemia. Por 28allele0, may explain interindividual variation in. In a retrospective study of 1,943 sulfonylurea pediatric poisonings, 10% of the children had hypoglycemia occurring or persisting more than 12 hours after ingestion despite receiving treatment.
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